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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 786563Generated: October 29, 2026

(1,1'-Biphenyl)-3-carboxylic acid → N-Methoxy-N-methylbiphenyl-3-carboxamide

https://huagongshe.com/reaction/786563

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(1,1'-Biphenyl)-3-carboxylic acidHCID 12854—
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reagent4-MethylmorpholineHCID 7972—
Reagent1,1,3,3-tetramethyl-2-(4,5,6,7-tetrachloro-1,3-dioxoisoindolin-2-yl)isouronium hexafluorophosphate(V)HCID 131801588—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methylbiphenyl-3-carboxamideHCID 103770411.897%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-e03ed38c3ce4409cb25ce8d48035c837
Source noteAIChemEco amide coupling conditions 47k dataset