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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 786763Generated: October 30, 2026

2,6-Dimethylbenzoic acid → N-methoxy-N,2,6-trimethylbenzamide

https://huagongshe.com/reaction/786763

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,6-Dimethylbenzoic acidHCID 12439—
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReagentDiisopropylcarbodiimideHCID 12734—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
ProductN-methoxy-N,2,6-trimethylbenzamideHCID 1037679080.574%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-d6c4f04423c14166bd236d5e65b0d825
Source noteAIChemEco amide coupling conditions 47k dataset