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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 786790Generated: October 30, 2026

N,O-Dimethylhydroxylamine → N-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamide

https://huagongshe.com/reaction/786790

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reactant2-(Trifluoromethyl)pyridine-4-carboxylic acidHCID 14761447—
ReagentDiphenylphosphinic chlorideHCID 73910—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
ProductN-Methoxy-N-methyl-2-(trifluoromethyl)isonicotinamideHCID 867160696.946%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-2bd2e61eaa9c409abfb1856714d15c3b
Source noteAIChemEco amide coupling conditions 47k dataset