反应详情

温度

60 °C

In an alternate embodiment, 1-(2-isocyanobenzyl)-3-methylurea (30 g), acetic acid (105 ml) and malonic acid (18 g) were mixed and heated to 60° C. Acetic anhydride (60 ml) was added at 60° C. and heating was continued for two hours at 80° C. The reaction mixture was poured over ice water (300 ml) and the obtained solid was filtered, washed with water (1×500 ml) and methyl-tert-butylether (100 ml). The yield is 60% with 93.4% purity.

1. temperatureheating
2. filtrationthe obtained solid was filtered
3. washwashed with water (1×500 ml) and methyl-tert-butylether (100 ml)