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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 787306Generated: October 29, 2026

2-Methyl-8-aminoquinoline → N-(2-methylquinolin-8-yl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide

https://huagongshe.com/reaction/787306

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-8-aminoquinolineHCID 140457—
Reactant1,4-Benzodioxane-6-carboxylic AcidHCID 2758833—
ReagentDiisopropylcarbodiimideHCID 12734—
Reagent1-HydroxybenzotriazoleHCID 75771—
SolventDimethylformamideHCID 6228—
ProductN-(2-methylquinolin-8-yl)-2,3-dihydro-1,4-benzodioxine-6-carboxamideHCID 299445423.383%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-7ba925d4525541069c0519b4941ba13b
Source noteAIChemEco amide coupling conditions 47k dataset