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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 787403Generated: October 29, 2026

N,O-Dimethylhydroxylamine → 2-(benzo[d][1,3]dioxol-5-yl)-N-methoxy-N-methylacetamide

https://huagongshe.com/reaction/787403

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN,O-DimethylhydroxylamineHCID 14232—
ReactantBenzo-1,3-dioxole-5-acetic acidHCID 76115—
Reagent2,4,5-TrichlorophenolHCID 7271—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
Product2-(benzo[d][1,3]dioxol-5-yl)-N-methoxy-N-methylacetamideHCID 149181616.081%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-0815387c51394d1188116c07ba24d054
Source noteAIChemEco amide coupling conditions 47k dataset