Ethanol → Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate

HRID 78749Notes

Reaction equation

HRID 78749 reaction equation
[CH2:1]([O:3][C:4](=[O:12])[C:5]([C:7]1[CH2:11][CH2:10][O:9][CH:8]=1)=[O:6])[CH3:2].[CH2:13]([OH:15])[CH3:14]>ClCCl>[CH2:1]([O:3][C:4](=[O:12])[C:5]([CH:7]1[CH2:11][CH2:10][O:9][CH:8]1[O:15][CH2:13][CH3:14])=[O:6])[CH3:2]

Participants

4

Reactant 2

HCID 702EthanolHCID 11571862HCID 11571862, compound

Product 1

HCID 67607633Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
45 °C

Procedure

Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate (10 g) was dissolved in Ethanol (50 ml) and Dichloromethane (50 ml). The reaction mass was stirred at 40-50° C. for 12 hrs. Reaction mass was concentrated to residue under vacuum at 40° C. Residue was dissolved in dichloromethane (50 ml) and washed with water (50 ml). Reaction mass was concentrated to residue to get ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (Yield 9.9 g).

Workup

  1. customReaction mass
  2. concentrationwas concentrated to residue under vacuum at 40° C
  3. dissolutionResidue was dissolved in dichloromethane (50 ml)
  4. washwashed with water (50 ml)
  5. customReaction mass
  6. concentrationwas concentrated to residue

Sources & evidence

ORD record
ord-6141a388ef844357989524e640371ea6
Source dataset
uspto-grants-2014_09
Patent number
US08841467B2

Reaction notes

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