反应详情

温度

45 °C

Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate (10 g) was dissolved in Ethanol (50 ml) and Dichloromethane (50 ml). The reaction mass was stirred at 40-50° C. for 12 hrs. Reaction mass was concentrated to residue under vacuum at 40° C. Residue was dissolved in dichloromethane (50 ml) and washed with water (50 ml). Reaction mass was concentrated to residue to get ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (Yield 9.9 g).

1. customReaction mass
2. concentrationwas concentrated to residue under vacuum at 40° C
3. dissolutionResidue was dissolved in dichloromethane (50 ml)
4. washwashed with water (50 ml)
5. customReaction mass
6. concentrationwas concentrated to residue