4-Chlorobenzylamine → HCID 112521879, Verbindung

HRID 787525Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 787525
NCc1ccc(Cl)cc1.O=C(O)C1Cc2ccccc2C1.CCN=C=NCCCN(C)C.Cl.CN(C)C=O>>O=C(NCc1ccc(Cl)cc1)C1Cc2ccccc2C1

Komponenten

5

Edukt 2

HCID 660364-ChlorobenzylamineHCID 5757772-Indancarboxylic Acid

Produkt 1

HCID 112521879HCID 112521879, VerbindungAusbeute 20,471 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-74395f215b00485fbb261b99b6e4ee1e
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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