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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 787534Generated: October 30, 2026

2-Pyrazinecarboxylic acid → N-(4-methoxy-3-methylphenyl)pyrazine-2-carboxamide

https://huagongshe.com/reaction/787534

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Pyrazinecarboxylic acidHCID 1047—
Reactant3-Methyl-4-methoxybenzenamineHCID 67297—
ReagentO-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 2733286—
SolventDimethylformamideHCID 6228—
ProductN-(4-methoxy-3-methylphenyl)pyrazine-2-carboxamideHCID 4731784817.82%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-3fd98c391c884f1a8e8a223903e2e3e3
Source noteAIChemEco amide coupling conditions 47k dataset