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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 78768Generated: October 25, 2026

4-Iodo-o-toluidine → 3-[(2-Methyl-4-iodophenyl)amino]isonicotinic acid

https://huagongshe.com/reaction/78768

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Iodo-o-toluidineHCID 83221—
Reactant2-Fluoroisonicotinic acidHCID 345360—
Product3-[(2-Methyl-4-iodophenyl)amino]isonicotinic acidHCID 57649617—

Reaction Steps

synthesized as intermediate 1 by reacting 4.7 mmol of 2-methyl-4-iodoaniline with 7.0 mmol 2-fluoroisonicotinic acid. LC/MS [(5.3 min; 355 (M+1)]. See detailed procedure in Example 3.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08841459B2
Source datasetuspto-grants-2014_09
ORD IDord-6293048581e545d2bbc6a70e93acc1cf
Source noteuspto-grants-2014_09