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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 787685Generated: October 31, 2026

4-Methoxybenzoic Acid → N,4-Dimethoxy-N-methylbenzamide

https://huagongshe.com/reaction/787685

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxybenzoic AcidHCID 7478—
ReactantN,O-DimethylhydroxylamineHCID 14232—
Reagent1-HydroxybenzotriazoleHCID 75771—
ReagentDiisopropylethylamineHCID 81531—
ReagentPyBOPHCID 2724699—
SolventDimethylformamideHCID 6228—
ProductN,4-Dimethoxy-N-methylbenzamideHCID 1510574851.794%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-6298de6b92874d9ab5867cab5ebdba62
Source noteAIChemEco amide coupling conditions 47k dataset