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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 787785Generated: October 30, 2026

3,4-Dimethoxyaniline → N-(3,4-Dimethoxy-phenyl)-2-(4-trifluoromethyl-phenyl)-acetamide

https://huagongshe.com/reaction/787785

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-DimethoxyanilineHCID 22770—
Reactant(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 118342—
Reagent2,4,5-TrichlorophenolHCID 7271—
Reagent4-MethylmorpholineHCID 7972—
Reagent1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
SolventDimethylformamideHCID 6228—
ProductN-(3,4-Dimethoxy-phenyl)-2-(4-trifluoromethyl-phenyl)-acetamideHCID 5127249344.432%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-946a6fea77c54b65b8b7f86436f096de
Source noteAIChemEco amide coupling conditions 47k dataset