Benzylamine → N-benzyl-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

HRID 78789Notes

Reaction equation

HRID 78789 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[CH2:19]([NH2:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH2:19]([NH:26][C:12](=[O:14])[C:11]1[CH:15]=[CH:16][N:17]=[CH:18][C:10]=1[NH:9][C:3]1[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=1[F:1])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2×

Product 1

HCID 11669510N-benzyl-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

Procedure

N-benzyl-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.3 mmol 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.45 mmol of benzylamine. LC/MS [7.55 min; 448 (M+1)]

Workup

  1. customLC/MS [7.55 min; 448 (M+1)]

Sources & evidence

ORD record
ord-6f1c1b9ce3d248e5b6897103b820137d
Source dataset
uspto-grants-2014_09
Patent number
US08841459B2

Reaction notes

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