N-Aminomorpholine → 3-[(2-fluoro-4-iodophenyl)amino]-N-morpholin-4-ylisonicotinamide

HRID 78792Notes

Reaction equation

HRID 78792 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[N:19]1([NH2:25])[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:25][N:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1)=[O:14]

Participants

3

Reactant 2

HCID 20315N-AminomorpholineHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2×

Product 1

HCID 115758383-[(2-fluoro-4-iodophenyl)amino]-N-morpholin-4-ylisonicotinamide

Procedure

3-[(2-fluoro-4-iodophenyl)amino]-N-morpholin-4-ylisonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.5 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.81 mmol of morpholin-4-ylamine LC/MS [8.25 min; 443 (M+1)]

Sources & evidence

ORD record
ord-863f9b92e6244401949b0acc260ea5c8
Source dataset
uspto-grants-2014_09
Patent number
US08841459B2

Reaction notes

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