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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 78797Generated: October 25, 2026

1-(3-Aminopropyl)-2-pyrrolidinone → 3-[(2-fluoro-4-iodophenyl)amino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]isonicotinamide

https://huagongshe.com/reaction/78797

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(3-Aminopropyl)-2-pyrrolidinoneHCID 82111—
Reactant3-((2-Fluoro-4-iodophenyl)amino)isonicotinic acidHCID 59026791—
Product3-[(2-fluoro-4-iodophenyl)amino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]isonicotinamideHCID 11648689—

Reaction Steps

3-[(2-fluoro-4-iodophenyl)amino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.6 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.85 mmol of 1-(3-amino-propyl)-pyrrolidin-2-one LC/MS [8.70 min; 483 (M+1)].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08841459B2
Source datasetuspto-grants-2014_09
ORD IDord-806cb2c300634d04bb6f023661f7b0f1
Source noteuspto-grants-2014_09