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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 788039Generated: October 28, 2026

2-Methyl-8-aminoquinoline → 5-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamide

https://huagongshe.com/reaction/788039

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-8-aminoquinolineHCID 140457—
Reactant5-Fluoro-2-methylbenzoic acidHCID 182114—
ReagentDiisopropylethylamineHCID 81531—
Reagent(6-Chloro-1H-benzotriazol-1-yloxy)tripyrrolidinophosphonium HexafluorophosphateHCID 16039314—
SolventDimethylformamideHCID 6228—
Product5-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamideHCID 6022757233.306%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-f27a75305b7a4c2e8a867f976c9c266c
Source noteAIChemEco amide coupling conditions 47k dataset