1-Aminohomopiperidine → N-azepan-1-yl-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

HRID 78808Notes

Reaction equation

HRID 78808 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[N:19]1([NH2:26])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[N:19]1([NH:26][C:12](=[O:14])[C:11]2[CH:15]=[CH:16][N:17]=[CH:18][C:10]=2[NH:9][C:3]2[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=2[F:1])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 221981-AminohomopiperidineHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2×

Product 1

HCID 57649645N-azepan-1-yl-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide

Procedure

N-azepan-1-yl-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.45 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 6.2 mmol of azepan-1-ylamine. LC/MS [8.99 min; 455 (M+1)]

Workup

  1. customLC/MS [8.99 min; 455 (M+1)]

Sources & evidence

ORD record
ord-8d863f0e6d2c4898bf427c22ab7065eb
Source dataset
uspto-grants-2014_09
Patent number
US08841459B2

Reaction notes

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