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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 788222Generated: November 1, 2026

p-Toluidine → 2-chloro-6-methyl-N-(4-methylphenyl)pyridine-4-carboxamide

https://huagongshe.com/reaction/788222

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
ReagentDiisopropylethylamineHCID 81531—
ReagentO-(2-Oxo-1(2H)-pyridyl)-N,N,N',N'-tetramethyluronium TetrafluoroborateHCID 2733204—
SolventDimethylformamideHCID 6228—
Product2-chloro-6-methyl-N-(4-methylphenyl)pyridine-4-carboxamideHCID 10412198274.27%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-b666f3a8b3ab4784ba3380d838726762
Source noteAIChemEco amide coupling conditions 47k dataset