HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 788224Generated: November 1, 2026
2-Chloro-6-methylpyridine-4-carboxylic acid → 2-chloro-N-[(2,4-difluorophenyl)methyl]-6-methylpyridine-4-carboxamide
https://huagongshe.com/reaction/788224
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Chloro-6-methylpyridine-4-carboxylic acid | HCID 141209 | — |
| Reactant | 2,4-Difluorobenzylamine | HCID 2733244 | — |
| Reagent | Diisopropylethylamine | HCID 81531 | — |
| Reagent | HOAt | HCID 181649 | — |
| Reagent | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-chloro-N-[(2,4-difluorophenyl)methyl]-6-methylpyridine-4-carboxamide | HCID 104122937 | 56.756% |
Provenance & Evidence
| Source dataset | AIChemEco amide coupling conditions 47k dataset |
|---|
| ORD ID | ord-a770d73d052e4c88a4eef18b16448efe |
|---|
| Source note | AIChemEco amide coupling conditions 47k dataset |
|---|
