1H-Imidazole-1-propanamine → 2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(3-imidazol-1-yl-propyl)-isonicotinamide

Participants

Role	Name	HCID	Charge
Reactant	1H-Imidazole-1-propanamine	HCID 78736	—
Reactant	2-Bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid	HCID 57649649	—
Product	2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(3-imidazol-1-yl-propyl)-isonicotinamide	HCID 11599171	—

Reaction Steps

2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(3-imidazol-1-yl-propyl)-isonicotinamide was synthesized according to the General Method 3, starting with 145 mg (0.33 mmol) of 2-bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid and 103 mg (0.83 mmol) of 3-Imidazol-1-yl-propylamine. Yield: 55 mg, 30%, LC/MS: [7.31 min, 545 (M+1)]

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08841459B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-b1668833d0f94a5693277f3d184a5424
Source note	uspto-grants-2014_09