Ethanolamine → 2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethyl)-isonicotinamide

HRID 78833Notes

Reaction equation

HRID 78833 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([I:18])=[CH:14][C:13]=2[F:19])=[CH:9][N:10]=1)[C:5]([OH:7])=O.[NH2:20][CH2:21][CH2:22][OH:23]>>[Br:1][C:2]1[CH:3]=[C:4]([C:8]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([I:18])=[CH:14][C:13]=2[F:19])=[CH:9][N:10]=1)[C:5]([NH:20][CH2:21][CH2:22][OH:23])=[O:7]

Participants

3

Reactant 2

HCID 700EthanolamineHCID 576496492-Bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid

Product 1

HCID 116126862-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethyl)-isonicotinamide

Procedure

2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethyl) -isonicotinamide was synthesized according to General Method 3, starting with 145 mg (0.33 mmol) of 2-bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid 51 mg (0.83 mmol) of 2-amino-ethanol. LC/MS: [8.98 min, 480, 482]

Workup

  1. custom[8.98 min, 480, 482]

Sources & evidence

ORD record
ord-9da2f5cf78f24637be3fa0d3ac6b978f
Source dataset
uspto-grants-2014_09
Patent number
US08841459B2

Reaction notes

Loading…