2-Morpholinoethylamine → 2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(2-morpholin-4-yl-ethyl)-isonicotinamide

Participants

Role	Name	HCID	Charge
Reactant	2-Morpholinoethylamine	HCID 408285	—
Reactant	2-Bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid	HCID 57649649	—
Product	2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(2-morpholin-4-yl-ethyl)-isonicotinamide	HCID 11685376	—

Reaction Steps

2-Bromo-5-(2-fluoro-4-iodo-phenylamino)-N-(2-morpholin-4-yl-ethyl)-isonicotinamide was synthesized according to the General Method 3 starting with 145 mg (0.33 mmol) of 2-bromo-5-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid and 108 mg (0.83 mmol) of 2-morpholin-4-yl-ethylamine. Yield: 95 mg, 52%. LC/MS: [7.08 min, 550, 552 (M+1)]

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08841459B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-36d1e24806194736a6a49cae7b998a07
Source note	uspto-grants-2014_09