(Aminooxy)acetic acid → [({3-[(2-Fluoro-4-iodophenyl)amino]isonicotinoyl}amino)oxy]acetic acid

HRID 78846Notes

Reaction equation

HRID 78846 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[O:19]([CH2:21][C:22]([OH:24])=[O:23])[NH2:20]>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:20][O:19][CH2:21][C:22]([OH:24])=[O:23])=[O:14]

Participants

3

Reactant 2

HCID 286(Aminooxy)acetic acidHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2×

Product 1

HCID 11597183[({3-[(2-Fluoro-4-iodophenyl)amino]isonicotinoyl}amino)oxy]acetic acid

Procedure

[({3-[(2-fluoro-4-iodophenyl)amino]isonicotinoyl}amino)oxy]acetic acid was synthesized according to the procedure for General Method 1, outlined above, starting with 0.3 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.51 mmol of aminoxy-acetic acid. LC/MS [5.21 min; 432 (M+1)]

Workup

  1. customLC/MS [5.21 min; 432 (M+1)]

Sources & evidence

ORD record
ord-20a7fabeceff41cf8c8ca6207fcc5ac9
Source dataset
uspto-grants-2014_09
Patent number
US08841459B2

Reaction notes

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