L-Serinamide → N-(1-(S)-Carbamoyl-2-hydroxy-ethyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide

HRID 78857Notes

Reaction equation

HRID 78857 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[NH2:19][C@H:20]([C:23]([NH2:25])=[O:24])[CH2:21][OH:22]>>[C:23]([C@@H:20]([NH:19][C:12](=[O:14])[C:11]1[CH:15]=[CH:16][N:17]=[CH:18][C:10]=1[NH:9][C:3]1[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=1[F:1])[CH2:21][OH:22])(=[O:24])[NH2:25]

Participants

3

Reactant 2

HCID 101138L-SerinamideHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2×

Product 1

HCID 57649641N-(1-(S)-Carbamoyl-2-hydroxy-ethyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide

Procedure

N-(1-(S)-Carbamoyl-2-hydroxy-ethyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.30 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.45 mmol of L-serinamide. LC/MS [5.09 min; 445 (M+1)]

Workup

  1. customLC/MS [5.09 min; 445 (M+1)]

Sources & evidence

ORD record
ord-f1edc2bb8b234e67b54fa6a39cece9ab
Source dataset
uspto-grants-2014_09
Patent number
US08841459B2

Reaction notes

Loading…