HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Iodo-o-toluidine → 2-Chloro-3-(2-fluoro-4-iodophenylamino)-isonicotinic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Iodo-o-toluidine | HCID 83221 | — |
| Reactant | 3-Chloro-2-fluoropyridine-4-carboxylic acid | HCID 12175428 | — |
| Reactant | 3-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid | HCID 59026791 | — |
| Product | 2-Chloro-3-(2-fluoro-4-iodophenylamino)-isonicotinic acid | HCID 57649634 | — |
Reaction Steps
2-Chloro-3-(2-fluoro-4-iodo-phenylamino)-isonicotinic acid was synthesized as outlined in General Method 1 and according to the procedure for the synthesis of intermediate 1 by reacting 4 mmol of 2-methyl-4-iodoaniline with 6 mmol 2-fluoro-3-chloro-isonicotinic acid. LC/MS [10.25 min; 390.9 (M−1)-ESI-].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841459B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-711002fca8c649d4bb18a7cce41ecffc |
| Source note | uspto-grants-2014_09 |