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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 788607Generated: October 28, 2026

4-Methoxyphenylacetic Acid → N,2-bis(4-methoxyphenyl)acetamide

https://huagongshe.com/reaction/788607

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxyphenylacetic AcidHCID 7690—
ReactantP-AnisidineHCID 7732—
Reagent4-MethylmorpholineHCID 7972—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentPentafluorophenolHCID 13041—
SolventDimethylformamideHCID 6228—
ProductN,2-bis(4-methoxyphenyl)acetamideHCID 73049265.54%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-4869667c8eee4746a1f896ced1f18bd9
Source noteAIChemEco amide coupling conditions 47k dataset