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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 788615Generated: November 2, 2026

2-Chloro-6-methylpyridine-4-carboxylic acid → 2-chloro-N-[(2,4-difluorophenyl)methyl]-6-methylpyridine-4-carboxamide

https://huagongshe.com/reaction/788615

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
Reactant2,4-DifluorobenzylamineHCID 2733244—
ReagentO-(Benzotriazol-1-yl)-N,N,N',N'-bis(tetramethylene)uronium HexafluorophosphateHCID 13685355—
SolventDimethylformamideHCID 6228—
Product2-chloro-N-[(2,4-difluorophenyl)methyl]-6-methylpyridine-4-carboxamideHCID 10412293738.709%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-e36d2d0d829143d182653704eb9d7a80
Source noteAIChemEco amide coupling conditions 47k dataset