反应详情

温度

200 °C

A mixture of 2-butyl-6-fluoro-5-methoxy-1-indanone (2.0 g) and pyridine hydrochloride (15.0 g) was heated in an oil bath at 200° C. for 75 minutes. After cooling to room temperature, the mixture was partitioned between EtOAc (100 mL) and water (75 mL) containing brine (25 mL). The organic phase was washed with brine (50 mL), dried over MgSO4, filtered, and evaporated under vacuum to provide 2-butyl-6-fluoro-5-hydroxy-1-indanone (1.79 g) as a solid.

1. temperatureAfter cooling to room temperature
2. customthe mixture was partitioned between EtOAc (100 mL) and water (75 mL)
3. additioncontaining brine (25 mL)
4. washThe organic phase was washed with brine (50 mL)
5. dry with materialdried over MgSO4
6. filtrationfiltered
7. customevaporated under vacuum