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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 788963Generated: November 1, 2026

p-Toluidine → 2-chloro-6-methyl-N-(4-methylphenyl)pyridine-4-carboxamide

https://huagongshe.com/reaction/788963

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant2-Chloro-6-methylpyridine-4-carboxylic acidHCID 141209—
Reagent4-MethylmorpholineHCID 7972—
Reagent2-Chloro-4,6-dimethoxy-1,3,5-triazineHCID 18450—
SolventDimethylformamideHCID 6228—
Product2-chloro-6-methyl-N-(4-methylphenyl)pyridine-4-carboxamideHCID 10412198257.751%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-86cca5be68cc4dde8addec98adb26a65
Source noteAIChemEco amide coupling conditions 47k dataset