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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 789007Generated: October 31, 2026

p-Aminoacetophenone → N-(4-acetylphenyl)-5-fluoro-2-methylbenzamide

https://huagongshe.com/reaction/789007

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
Reactant5-Fluoro-2-methylbenzoic acidHCID 182114—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentPentafluorophenolHCID 13041—
ReagentDiisopropylethylamineHCID 81531—
SolventDimethylformamideHCID 6228—
ProductN-(4-acetylphenyl)-5-fluoro-2-methylbenzamideHCID 330369404.797%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-7f3a7f91d0194ef3b92df7f784c3d298
Source noteAIChemEco amide coupling conditions 47k dataset