HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(4-bromo-benzyl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 4-Bromobenzaldehyde | HCID 70741 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | Cis-(6-benzhydryl-tetrahydropyran-3-yl)-amine | HCID 11565229 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Cis-(6-benzhydryl-tetrahydropyran-3-yl)-(4-bromo-benzyl)-amine | HCID 66631020 | 80% |
Reaction Steps
Trans-5-amino-2-diphenylmethyl-tetrahydropyran 15 (0.04 g, 0.15 mmol) was reacted with 4-bromobenzaldehyde (0.028 g, 0.15 mmol) in the presence of glacial acetic acid (0.009 g, 0.15 mmol) in 1,2-dichloroethane (20 ml), and NaCNBH3 (0.012 g, 0.18 mmol) in methanol (5 ml) (Procedure D) to give compound 16l (0.052 g, 80%) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841464B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-1bed559114ea41f481ac7daff3b44161 |
| Source note | uspto-grants-2014_09 |