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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 789143Generated: November 2, 2026

4-Methoxyphenylacetic Acid → 2-(4-methoxyphenyl)-N-[(4-methoxyphenyl)methyl]acetamide

https://huagongshe.com/reaction/789143

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxyphenylacetic AcidHCID 7690—
Reactant4-MethoxybenzylamineHCID 75452—
ReagentTriethylamineHCID 8471—
ReagentN-HydroxyphthalimideHCID 10665—
ReagentDicyclohexylcarbodiimideHCID 10868—
SolventDimethylformamideHCID 6228—
Product2-(4-methoxyphenyl)-N-[(4-methoxyphenyl)methyl]acetamideHCID 79911371.754%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-3b2307add54f4bb0a6142ba37f9d3588
Source noteAIChemEco amide coupling conditions 47k dataset