HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzylamine → (2S,4R,5R)-2-benzhydryl-5-(4-fluoro-benzylamino)-tetrahydropyran-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzylamine | HCID 67326 | — |
| Reactant | (1S,4S,6R)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane | HCID 54762329 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (2S,4R,5R)-2-benzhydryl-5-(4-fluoro-benzylamino)-tetrahydropyran-4-ol | HCID 11303888 | — |
Reaction Steps
(1S,4S,6R)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane 28a (0.025 g, 0.094 mmol) was reacted with para-fluoro-benzylamine (0.24 g, 1.88 mmol) in ethanol (Procedure E) to yield (2S,4R,5R)-2-benzhydryl-5-(4-fluoro-benzylamino)-tetrahydropyran-4-ol, (−)-29b, 0.032 g (86%, [α]D=(−)77.2, c=1, MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841464B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-c09801b31ea644a3a7cee90af5e07934 |
| Source note | uspto-grants-2014_09 |