HRID78935

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4653

p-Fluorophenethylamine

C8H10FN

结构：c1ccc(C(c2ccccc2)[C@H]2C[C@@H]3O[C@@H]3CO2)cc1

HCID86605347

未命名化合物

PRODUCTS

生成物

结构：O[C@H]1C[C@H](C(c2ccccc2)c2ccccc2)OC[C@@H]1NCCc1ccc(F)cc1

HCID11350257

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

(1R,4R,6S)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane 28c (0.02 g, 0.075 mmol) was reacted with 2-(4-fluorophenyl)-ethylamine (0.21 g, 1.50 mmol) in ethanol (Procedure E) to yield (2R,4S,5S)-2-benzhydryl-5-[2-(4-fluorophenyl)-ethylamino]-tetrahydropyran-4-ol, (+)-29c, 0.030 g (98%, [α]D=(+)63.4, c=1, MeOH).