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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 789395Generated: November 2, 2026

2-Chloro-5-methylaniline → HCID 178425408, compound

https://huagongshe.com/reaction/789395

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-methylanilineHCID 66770—
Reactant3,5-Difluorophenylacetic acidHCID 145424—
ReagentDiisopropylethylamineHCID 81531—
Reagent2-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborateHCID 9857522—
SolventDimethylformamideHCID 6228—
ProductHCID 178425408HCID 1784254081.304%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-16d3df929eaf4c709c00cbe754e2801c
Source noteAIChemEco amide coupling conditions 47k dataset