HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → Trans-6-benzhydryl-tetrahydropyran-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | (1R,4R,6S)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane | HCID 86605347 | — |
| Solvent | Pentane | HCID 8003 | — |
| Product | Trans-6-benzhydryl-tetrahydropyran-3-ol | HCID 11608697 | 70% |
Reaction Steps
(1R,4R,6S)-4-benzhydryl-3,7-dioxa-bicyclo[4.1.0]-heptane (0.05 g, 0.19 mmol) was treated with LiAlH4 (0.036 g, 0.94 mmol) (Procedure I) in dry pentane to yield trans-(3S,6R)-6-benzhydryl-tetrahydro-pyran-3-ol 33b 0.035 g (70%, [α]D=(+)61.7, c=1, MeOH).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841464B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-5822be276e24439c935abf218252ab2f |
| Source note | uspto-grants-2014_09 |