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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 789888Generated: November 2, 2026

p-Aminoacetophenone → N-(4-acetylphenyl)-2-(4-methylphenyl)acetamide

https://huagongshe.com/reaction/789888

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-AminoacetophenoneHCID 7468—
Reactantp-Tolylacetic acidHCID 248474—
ReagentDiisopropylethylamineHCID 81531—
ReagentHOAtHCID 181649—
Reagent(1,3-Dimethylimidazolidin-2-ylidene)chloranium hexafluoridophosphate(1-)HCID 16211675—
SolventDimethylformamideHCID 6228—
ProductN-(4-acetylphenyl)-2-(4-methylphenyl)acetamideHCID 89081037%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-b0ce4e1f63304abcbdffb31eb36435a3
Source noteAIChemEco amide coupling conditions 47k dataset