HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1-(2-Oxo-2-thiophen-2-yl-acetyl)piperidine-2-carboxylic acid N'-(6-methyl-4-trifluoromethyl-pyridin-2-yl)-hydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | PyBroP | HCID 2733179 | — |
| Reactant | 1-(6-Methyl-4-(trifluoromethyl)-2-pyridyl)hydrazine | HCID 2775684 | — |
| Reactant | 1-[1,2-Dioxo-2-(thien-2-yl)ethyl)-2-piperidinecarboxylic acid | HCID 9816804 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(2-Oxo-2-thiophen-2-yl-acetyl)piperidine-2-carboxylic acid N'-(6-methyl-4-trifluoromethyl-pyridin-2-yl)-hydrazide | HCID 10138135 | — |
Reaction Steps
From Intermediate 3 (267 mg, 1 mmol), 2-hydrazino-6-methyl-4-trifluoromethylpyridine (191 mg, 1 mmol), PyBrop (466 mg, 1 mmol), DMAP (122 mg) and DIEA (2 mL) in THF (30 mL), using the same procedure for Compound 1, the title compound was obtained as a white solid; 110 mg (25%). MS (m/z) 441 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07087628B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-617a12e0035e4410b97f42be63d9aec7 |
| Source note | uspto-grants-2006_08 |