HCID 86656242, compound → 4-(2-Fluoro-4-iodophenylamino)-1H-pyrazolo[3,4-b]pyridine 5-carboxylic acid (2-hydroxyethoxy)-amide

Participants

Reaction Conditions

Reaction Steps

4-(2-Fluoro-4-iodophenylamino)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid (2-vinyloxyethoxy)-amide (346 mg, 0.57 mmol) was dissolved in TFA (5 mL) and the reaction mixture heated at 65° C. for 3 hours. The reaction mixture was concentrated in vacuo and the residue was dissolved in ethyl acetate (10 mL), washed with aqueous saturated sodium bicarbonate solution (10 mL) and the aqueous fraction extracted twice with ethyl acetate (2×10 mL). The combined organic extracts were washed with brine (20 mL), dried (MgSO4) and concentrated in vacuo. The resultant residue was subjected to flash chromatography (Si—SPE, gradient 0-10% methanol in DCM) to yield the title compound as a yellow solid (75 mg, 30%). LCMS (Method A): RT=6.67 min, [M+H]+=458. 1H NMR (DMSO-d6, 400 MHz) 13.51 (1H, s), 11.75 (1H, s), 10.38 (1H, s), 8.45 (1H, s), 7.80 (1H, dd, J=9.67, 1.86 Hz), 7.64-7.60 (1H, m), 7.30-7.21 (1H, m), 6.74 (1H, s), 4.71 (1H, s), 3.90 (2H, t, J=4.95 Hz), 3.61-3.56 (3H, m).

Provenance & Evidence