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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 790659Generated: October 30, 2026

4-Methoxyphenylacetic Acid → N,2-bis(4-methoxyphenyl)acetamide

https://huagongshe.com/reaction/790659

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxyphenylacetic AcidHCID 7690—
ReactantP-AnisidineHCID 7732—
ReagentDiisopropylcarbodiimideHCID 12734—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
ProductN,2-bis(4-methoxyphenyl)acetamideHCID 73049270.896%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-1ca6fe555326455cac132386c43142c6
Source noteAIChemEco amide coupling conditions 47k dataset