2-[[4-[(difluoromethyl)thio]phenyl]amino]-N-[3-[[(2-furanylmethyl)amino]sulfonyl]phenyl]-benzamide → HCID 16580910, compound

HRID 79089Notes

Reaction equation

HRID 79089 reaction equation
N1C[CH2:3][CH2:4][C:5]=1[NH:6][S:7]([C:10]1[CH:11]=[C:12]([NH:16][C:17](=[O:31])[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:13]=[CH:14][CH:15]=1)(=[O:9])=[O:8].CN(C)S(C1C=C(NC(=O)C2C=CC=CC=2OC2C=CC=CC=2)C=CC=1)(=O)=O.CN(C)S(C1C=CC(OC)=C(NC(=O)C2C=CC=CC=2OC2C=CC=CC=2)C=1)(=O)=O.NS(C1C=C(NC(=O)C2C=C([N+]([O-])=O)C=CC=2OC2C=CC(OC)=CC=2)C=CC=1)(=O)=O.C1(NS(C2C=C(NC(=O)C3C=CC=CC=3CC3C=CC=CC=3)C=CC=2)(=O)=O)CC1.C(C1C=CC=CC=1SC1C=CC=CC=1C(NC1C=C(S(N(C)C)(=O)=O)C=C(C)C=1C)=O)#N.C(C1C=CC=CC=1SC1C=CC=CC=1C(NC1C=C(S(N(CC)CC)(=O)=O)C=C(C)C=1C)=O)#N.CN(C)S(C1C=CC(C)=C(NC(=O)C2C=CC=CC=2CC2C=CC=CC=2)C=1)(=O)=O.C(C1C=CC=CC=1SC1C=CC=CC=1C(NC1C=C(S(N(CC)CC)(=O)=O)C=CC=1C)=O)#N.CN(C)S(C1C=CC(C)=C(NC(=O)C2C=CC=CC=2SC2C=CC(C(F)(F)F)=CC=2[N+]([O-])=O)C=1)(=O)=O.C(C1C=CC=CC=1SC1C=CC=CC=1C(NC1C=C(S(N(CC)CC)(=O)=O)C=CC=1OC)=O)#N.NS(C1C=C(NC(=O)C2C=CC=CC=2C(=O)C2C=CC(SC)=C([N+]([O-])=O)C=2)C=CC=1OC)(=O)=O.ClC1C=CC(C(C2C=CC=CC=2C(NC2C=C(S(NCC)(=O)=O)C=CC=2OC)=O)=O)=CC=1[N+]([O-])=O.FC(F)SC1C=CC(NC2C=CC=CC=2C(NC2C=CC=C(S(NCC3OC=CC=3)(=O)=O)C=2)=O)=CC=1>>[CH:5]1([NH:6][S:7]([C:10]2[CH:11]=[C:12]([NH:16][C:17](=[O:31])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24][C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:13]=[CH:14][CH:15]=2)(=[O:9])=[O:8])[CH2:3][CH2:4]1

Participants

15

Reactant 14

HCID 41359952-[[4-[(difluoromethyl)thio]phenyl]amino]-N-[3-[[(2-furanylmethyl)amino]sulfonyl]phenyl]-benzamideHCID 4801068N-[5-[(dimethylamino)sulfonyl]-2-methoxyphenyl]-2-phenoxy-benzamideHCID 4801214HCID 4801214, compoundHCID 4852859N-[3-(aminosulfonyl)-4-methoxyphenyl]-2-[4-(methylthio)-3-nitrobenzoyl]-benzamideHCID 159923982-(4-chloro-3-nitrobenzoyl)-N-[5-[(ethylamino)sulfonyl]-2-methoxyphenyl]-benzamideHCID 162326332-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2-methoxyphenyl]-benzamideHCID 16256180N-[3-[[(3,4-dihydro-2H-pyrrol-5-yl)amino]sulfonyl]phenyl]-2-phenoxy-benzamideHCID 16272668N-[5-[(dimethylamino)sulfonyl]-2-methylphenyl]-2-[[2-nitro-4-(trifluoromethyl)phenyl]thio]-benzamideHCID 16545908N-[5-[(dimethylamino)sulfonyl]-2-methylphenyl]-2-(phenylmethyl)-benzamideHCID 16580911HCID 16580911, compoundHCID 44392658HCID 44392658, compoundHCID 691337732-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2,3-dimethylphenyl]-benzamideHCID 69133816HCID 69133816, compoundHCID 691338742-[(2-cyanophenyl)thio]-N-[5-[(dimethylamino)sulfonyl]-2,3-dimethylphenyl]-benzamide

Product 1

HCID 16580910HCID 16580910, compound

Procedure

N-[3-[[(3,4-dihydro-2H-pyrrol-5-yl)amino]sulfonyl]phenyl]-2-phenoxy-benzamide; N-[3-[(dimethylamino)sulfonyl]phenyl]-2-phenoxy-benzamide; N-[5-[(dimethylamino)sulfonyl]-2-methoxyphenyl]-2-phenoxy-benzamide; N-[3-(aminosulfonyl)phenyl]-2-(4-methoxyphenoxy)-5-nitro-benzamide; N-[3-[(cyclopropylamino)sulfonyl]phenyl]-2-(phenylmethyl)-benzamide; 2-[(2-cyanophenyl)thio]-N-[5-[(dimethylamino)sulfonyl]-2,3-dimethylphenyl]-benzamide; 2-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2,3-dimethylphenyl]-benzamide; N-[5-[(dimethylamino)sulfonyl]-2-methylphenyl]-2-(phenylmethyl)-benzamide; 2-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2-methylphenyl]-benzamide; N-[5-[(dimethylamino)sulfonyl]-2-methylphenyl]-2-[[2-nitro-4-(trifluoromethyl)phenyl]thio]-benzamide; 2-[(2-cyanophenyl)thio]-N-[5-[(diethylamino)sulfonyl]-2-methoxyphenyl]-benzamide; N-[3-(aminosulfonyl)-4-methoxyphenyl]-2-[4-(methylthio)-3-nitrobenzoyl]-benzamide; 2-(4-chloro-3-nitrobenzoyl)-N-[5-[(ethylamino)sulfonyl]-2-methoxyphenyl]-benzamide; and 2-[[4-[(difluoromethyl)thio]phenyl]amino]-N-[3-[[(2-furanylmethyl)amino]sulfonyl]phenyl]-benzamide.

Sources & evidence

ORD record
ord-95e52d2662b04cc1b91e7386b25cb31e
Source dataset
uspto-grants-2014_09
Patent number
US08841483B2

Reaction notes

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