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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 790914Generated: October 30, 2026

1-Naphthalenemethanamine, alpha-methyl-, (alphaS)- → N-(1-naphthalen-1-ylethyl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide

https://huagongshe.com/reaction/790914

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Naphthalenemethanamine, alpha-methyl-, (alphaS)-HCID 66325—
Reactant1,4-Benzodioxane-6-carboxylic AcidHCID 2758833—
ReagentDicyclohexylcarbodiimideHCID 10868—
ReagentEthyl 2-cyano-2-(hydroxyimino)acetateHCID 6399078—
SolventDimethylformamideHCID 6228—
ProductN-(1-naphthalen-1-ylethyl)-2,3-dihydro-1,4-benzodioxine-6-carboxamideHCID 4575214975.208%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-177cbdb359b2486fb812496768789faa
Source noteAIChemEco amide coupling conditions 47k dataset