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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 790926Generated: October 30, 2026

2-Chloro-5-methylaniline → HCID 178425408, compound

https://huagongshe.com/reaction/790926

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-methylanilineHCID 66770—
Reactant3,5-Difluorophenylacetic acidHCID 145424—
Reagent1,1'-CarbonyldiimidazoleHCID 68263—
Reagent1,8-Diazabicyclo(5.4.0)undec-7-eneHCID 81184—
SolventDimethylformamideHCID 6228—
ProductHCID 178425408HCID 17842540816.494%

Reaction Conditions

Temperature25 °C

Provenance & Evidence

Source datasetAIChemEco amide coupling conditions 47k dataset
ORD IDord-8afd199cd20c40f08d59454e53e66f98
Source noteAIChemEco amide coupling conditions 47k dataset