Potassium Phosphate, Tribasic → HCID 24855059, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Phosphate, Tribasic	HCID 62657	—
Reactant	2-(Piperidin-1-yl)phenol	HCID 3262250	—
Reactant	2-bromo-N-(3-(aminosulfonyl)phenyl)benzamide	HCID 26580511	—
Catalyst	Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)	HCID 24350	—
Solvent	Water	HCID 962	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 24855059	HCID 24855059	—

Reaction Conditions

Temperature	150 °C

Reaction Steps

A suspension of 2-bromo-N-(3-(aminosulfonyl)phenyl)benzamide (0.10 g, 0.28 mmol), 2-(piperidin-1-yl)phenol (74 mg, 0.28 mmol), K3PO4 (0.12 g, 0.56 mmol), and CuI (53 mg, 0.28 mmol) in DMF (1 mL) and water (20 μL) was sealed in a glass tube and heated in a microwave oven at 150° C. for 15 min. The reaction was filtered and purified by preparative reverse phase HPLC using 10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA) to give 2-(2-(piperidin-1-yl)phenoxy)-N-(3-(aminosulfonyl)phenyl)benzamide. LC/MS: m/z 452.0 (M+H)+ at 2.31 min (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08841483B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-8ff2be434a974ceb848b4bf55ae14d5c
Source note	uspto-grants-2014_09