HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetoxyacetyl chloride → HCID 58299757, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetoxyacetyl chloride | HCID 26297 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 9-Cyclopentyl-N-(5-Piperazin-1-Ylpyridin-2-Yl)pyrido[4,5]pyrrolo[1,2-D]pyrimidin-2-Amine | HCID 44132585 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58299757 | HCID 58299757 | — |
Reaction Steps
To a solution of compound 7 (207 mg, 0.50 mmol) in DMF (5 mL) were added N,N-diisopropylethylamine (174 uL, 1.0 mmol) and acetoxyacetyl chloride (65 uL, 0.60 mmol) and the resulted mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated to give compound 189 as a yellow solid which was used in next step without further purification. LCMS-ESI (POS), M/Z, M+1: Found 514.2, Calculated 514.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841312B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-f822fc4343994ca58574641caf41a9ee |
| Source note | uspto-grants-2014_09 |