反应详情

温度

100 °C

Compound 2 (2.00 g, 7.78 mmol), 2,6-dimethoxypyridin-3-ylboronic acid (2.13 g, 11.7 mmol), tris(dibenzylideneacetone)dipalladium (0) (0.214 g, 0.233 mmol), and dicyclohexyl(2,6-dimethoxyphenyl)phosphine (0.156 g, 0.467 mmol), were dissolved in n-butanol (2.5 mL). The reaction was purged with argon and heated at 100° C. for 19 hours. The resulting solution was added to 80 mL water and extracted with ethyl acetate (2×150 mL). The combined organics were dried (MgSO4) and evaporated to give an orange oil. Silica gel chromatography (gradient elution dichloromethane+2.5% TEA/0-5% methanol) afforded compound 267 as an off-white solid (1.29 g, 53%).

1. customThe reaction was purged with argon
2. additionThe resulting solution was added to 80 mL water
3. extractionextracted with ethyl acetate (2×150 mL)
4. dry with materialThe combined organics were dried (MgSO4)
5. customevaporated
6. customto give an orange oil
7. washSilica gel chromatography (gradient elution dichloromethane+2.5% TEA/0-5% methanol)