Hydrochloric Acid → HCID 58299570, compound

Participants

Reaction Steps

Compound 288 (44.0 mg, 81.5 μmol) was suspended in 3 mL methanol. Mmethanol saturated at room temperature with HCl (1 mL) was added, and the reaction stirred at room temperature for 2.5 hours. The solvents were removed in vacuo. The residue was taken up in methanol (10 mL) and stripped again to give compound 286 as a yellow solid (37 mg, 91%). 1H NMR (500 MHz, DMSO-d6) δ 1.68-1.80 (m, 2 H) 2.01-2.20 (m, 4 H) 2.64 (none, 2 H) 3.25-3.34 (m, 4 H) 3.34-3.44 (m, 5 H) 5.62-5.73 (m, 1 H) 7.60-7.73 (m, 1 H) 7.98-8.07 (m, 1 H) 8.09-8.16 (m, 1 H) 8.39-8.48 (m, 1 H) 8.58-8.65 (m, 1 H) 8.67-8.80 (m, 2 H) 9.40-9.49 (m, 1 H) 10.32-10.51 (m, 1 H) ppm.

Provenance & Evidence