4-carboxy-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-one → 4-carboxy-2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one

HRID 7919Notes

Reaction equation

HRID 7919 reaction equation
[C:1]([C:4]1[C:5](=[O:22])[N:6]([CH2:18][CH:19]([CH3:21])[CH3:20])[N:7]=[C:8]([C:10]2[CH:15]=[CH:14][C:13](C)=[C:12]([F:17])[CH:11]=2)[CH:9]=1)([OH:3])=[O:2].C1(CN2[C:32](=[O:33])C(OC)C(=C=O)C(C3C=CC(OC)=C(F)C=3)=N2)CC1>>[C:1]([C:4]1[C:5](=[O:22])[N:6]([CH2:18][CH:19]2[CH2:20][CH2:21]2)[N:7]=[C:8]([C:10]2[CH:15]=[CH:14][C:13]([O:33][CH3:32])=[C:12]([F:17])[CH:11]=2)[CH:9]=1)([OH:3])=[O:2]

Participants

3

Reactant 2

HCID 219914814-carboxy-6-(3-fluoro-4-methylphenyl)-2-isobutyl-2H-pyridazin-3-oneHCID 865975752-cyclo-propylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-methoxy-carbonyl-2H-pyridazin-3-one

Product 1

HCID 219914374-carboxy-2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-oneYield 98.9%

Procedure

Following the procedure of Example 1 (7), 2-cyclo-propylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-methoxy-carbonyl-2H-pyridazin-3-one was reacted to yield the title compound as yellow crystals (yield: 98.9%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-c710a98177e24ecea9f95a6057b7ad14
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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