4-carboxy-2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one → 2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-hydroxymethyl-2H-pyridazin-3-one

HRID 7920Notes

Reaction equation

HRID 7920 reaction equation
FC1C=C(C2C(C)=C(O)C(=O)N(CC(C)C)N=2)C=CC=1C.[C:22]([C:25]1[C:26](=[O:44])[N:27]([CH2:40][CH:41]2[CH2:43][CH2:42]2)[N:28]=[C:29]([C:31]2[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[C:33]([F:39])[CH:32]=2)[CH:30]=1)(O)=[O:23]>>[CH:41]1([CH2:40][N:27]2[C:26](=[O:44])[C:25]([CH2:22][OH:23])=[CH:30][C:29]([C:31]3[CH:36]=[CH:35][C:34]([O:37][CH3:38])=[C:33]([F:39])[CH:32]=3)=[N:28]2)[CH2:43][CH2:42]1

Participants

3

Reactant 2

HCID 219914374-carboxy-2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-oneHCID 178419042HCID 178419042, compound

Product 1

HCID 219916432-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-hydroxymethyl-2H-pyridazin-3-one

Procedure

Following the procedure of Example 1 (8), 4-carboxy-2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-2H-pyridazin-3-one was reacted to yield the title compound as slightly yellow fine-needles (yield: 21.3%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-29d215b07747424baa326c57ae8e04df
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

Loading…