6-(3-fluoro-4-methylphenyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-one → 2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-meth anesulfonyloxymethyl-2H-pyridazin-3-one

HRID 7921Notes

Reaction equation

HRID 7921 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[C:11]([CH2:20][O:21][S:22]([CH3:25])(=[O:24])=[O:23])[C:12](=[O:19])[N:13]([CH2:15][CH:16]([CH3:18])[CH3:17])[N:14]=2)[CH:5]=[CH:6][C:7]=1C.C1(CN2[C:35](=[O:36])C(CO)=CC(C3C=CC(OC)=C(F)C=3)=N2)CC1>>[CH:16]1([CH2:15][N:13]2[C:12](=[O:19])[C:11]([CH2:20][O:21][S:22]([CH3:25])(=[O:24])=[O:23])=[CH:10][C:9]([C:4]3[CH:5]=[CH:6][C:7]([O:36][CH3:35])=[C:2]([F:1])[CH:3]=3)=[N:14]2)[CH2:17][CH2:18]1

Participants

3

Reactant 2

HCID 219915316-(3-fluoro-4-methylphenyl)-2-isobutyl-4-methane-sulfonyloxymethyl-2H-pyridazin-3-oneHCID 219916432-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-hydroxymethyl-2H-pyridazin-3-one

Product 1

HCID 219916182-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl)-4-meth anesulfonyloxymethyl-2H-pyridazin-3-one

Procedure

Following the procedure of Example 1 (9), 2-cyclopropylmethyl-6-(3-fluoro-4-methoxyphenyl) -4-hydroxymethyl-2H-pyridazin-3-one was reacted to yield the title compound as slightly yellow needles (yield: 80.4%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-24caefb412d641299dc0356bb3b2eb83
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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